Assay Detail
Functional
CHEMBL5153128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated in presence of IBMX by cAMP-glo assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of 5-Amide-1<i>H</i>-pyrazole-3-carboxyl Derivatives as Potent P2Y<sub>14</sub>R Antagonists with Anti-Inflammatory Characters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 7.69 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208130 | — | — | 1 | 8.71 |
| CHEMBL1800685 | PPTN | — | 1 | 8.70 |
| CHEMBL5203559 | — | — | 1 | 8.42 |
| CHEMBL5194881 | — | — | 1 | 8.42 |
| CHEMBL5182459 | — | — | 1 | 8.40 |
| CHEMBL5175291 | — | — | 1 | 8.38 |
| CHEMBL5189241 | — | — | 1 | 8.33 |
| CHEMBL5192153 | — | — | 1 | 8.33 |
| CHEMBL5185002 | — | — | 1 | 8.32 |
| CHEMBL5195243 | — | — | 1 | 8.30 |
| CHEMBL5203936 | — | — | 1 | 8.27 |
| CHEMBL5182261 | — | — | 1 | 8.24 |
| CHEMBL5208342 | — | — | 1 | 8.15 |
| CHEMBL5169372 | — | — | 1 | 7.85 |
| CHEMBL5183974 | — | — | 1 | 7.80 |
| CHEMBL5205552 | — | — | 1 | 7.39 |
| CHEMBL5203764 | — | — | 1 | 7.21 |
| CHEMBL5188038 | — | — | 1 | 7.17 |
| CHEMBL5209515 | — | — | 1 | 7.00 |
| CHEMBL5181115 | — | — | 1 | 6.96 |
| CHEMBL5189945 | — | — | 1 | 6.87 |
| CHEMBL5170216 | — | — | 1 | 6.77 |
| CHEMBL5189099 | — | — | 1 | 6.64 |
| CHEMBL5194765 | — | — | 1 | 6.61 |
| CHEMBL5206480 | — | — | 1 | 6.43 |
| CHEMBL5205688 | — | — | 1 | 6.27 |
| CHEMBL5183561 | — | — | 1 | - |
| CHEMBL5209203 | — | — | 1 | - |
| CHEMBL5184856 | — | — | 1 | - |
| CHEMBL5187389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208130 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL1800685 | PPTN | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL5194881 | — | IC50 | = | 3.83 | nM | 8.42 |
| CHEMBL5203559 | — | IC50 | = | 3.81 | nM | 8.42 |
| CHEMBL5182459 | — | IC50 | = | 4.01 | nM | 8.40 |
| CHEMBL5175291 | — | IC50 | = | 4.16 | nM | 8.38 |
| CHEMBL5189241 | — | IC50 | = | 4.65 | nM | 8.33 |
| CHEMBL5192153 | — | IC50 | = | 4.66 | nM | 8.33 |
| CHEMBL5185002 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL5195243 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5203936 | — | IC50 | = | 5.39 | nM | 8.27 |
| CHEMBL5182261 | — | IC50 | = | 5.77 | nM | 8.24 |
| CHEMBL5208342 | — | IC50 | = | 7.11 | nM | 8.15 |
| CHEMBL5169372 | — | IC50 | = | 14.26 | nM | 7.85 |
| CHEMBL5183974 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5205552 | — | IC50 | = | 40.95 | nM | 7.39 |
| CHEMBL5203764 | — | IC50 | = | 61.22 | nM | 7.21 |
| CHEMBL5188038 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5209515 | — | IC50 | = | 99.65 | nM | 7.00 |
| CHEMBL5181115 | — | IC50 | = | 110.9 | nM | 6.96 |
| CHEMBL5189945 | — | IC50 | = | 135.7 | nM | 6.87 |
| CHEMBL5170216 | — | IC50 | = | 170.8 | nM | 6.77 |
| CHEMBL5189099 | — | IC50 | = | 227.3 | nM | 6.64 |
| CHEMBL5194765 | — | IC50 | = | 245.1 | nM | 6.61 |
| CHEMBL5206480 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL5205688 | — | IC50 | = | 531.5 | nM | 6.27 |
| CHEMBL5199447 | — | IC50 | - | — | - | |
| CHEMBL5208928 | — | IC50 | - | — | - | |
| CHEMBL5187483 | — | IC50 | - | — | - | |
| CHEMBL5201558 | — | IC50 | - | — | - | |
| CHEMBL5192477 | — | IC50 | - | — | - | |
| CHEMBL5203691 | — | IC50 | - | — | - | |
| CHEMBL5188554 | — | IC50 | - | — | - | |
| CHEMBL5204691 | — | IC50 | - | — | - | |
| CHEMBL5175975 | — | IC50 | - | — | - | |
| CHEMBL5173350 | — | IC50 | - | — | - | |
| CHEMBL5181431 | — | IC50 | - | — | - | |
| CHEMBL5173736 | — | IC50 | - | — | - | |
| CHEMBL5183561 | — | IC50 | - | — | - | |
| CHEMBL5183434 | — | IC50 | - | — | - | |
| CHEMBL5178378 | — | IC50 | - | — | - | |
| CHEMBL5171287 | — | IC50 | - | — | - | |
| CHEMBL5185373 | — | IC50 | - | — | - | |
| CHEMBL5205395 | — | IC50 | - | — | - | |
| CHEMBL5182974 | — | IC50 | - | — | - | |
| CHEMBL5208178 | — | IC50 | - | — | - | |
| CHEMBL5194585 | — | IC50 | - | — | - | |
| CHEMBL5187389 | — | IC50 | - | — | - | |
| CHEMBL5184856 | — | IC50 | - | — | - | |
| CHEMBL5209203 | — | IC50 | - | — | - |