Assay Detail

CHEMBL5153407

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Binding

Inhibition of ROCK2 (unknown origin)

ChEMBL ↗

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Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

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Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies.

Li G, Cheng Y, Han C, Song C, Huang N, Du Y.
RSC Med Chem (2022) 13 : 1300 -1321
PubMed 36439976 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.98	6.98

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2005186	BELUMOSUDIL	4.0	1	6.98

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2005186	BELUMOSUDIL	IC50	=	105.0	nM	6.98