Assay Detail
Binding
CHEMBL5153627
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Inhibition of HDAC1 (unknown origin)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.53 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177696 | — | — | 1 | 8.89 |
| CHEMBL5179582 | — | — | 1 | 8.59 |
| CHEMBL5187998 | — | — | 1 | 8.36 |
| CHEMBL5202912 | — | — | 1 | 8.24 |
| CHEMBL5191916 | — | — | 1 | 8.24 |
| CHEMBL5181688 | — | — | 1 | 8.23 |
| CHEMBL5202576 | — | — | 1 | 8.20 |
| CHEMBL5191744 | — | — | 1 | 7.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.77 |
| CHEMBL5178408 | — | — | 1 | 7.72 |
| CHEMBL5170820 | — | — | 1 | 7.66 |
| CHEMBL5179871 | — | — | 1 | 7.33 |
| CHEMBL5170945 | — | — | 1 | 7.16 |
| CHEMBL5204809 | — | — | 1 | 7.11 |
| CHEMBL5206740 | — | — | 1 | 6.90 |
| CHEMBL5186206 | — | — | 1 | 6.80 |
| CHEMBL5173348 | — | — | 1 | 6.80 |
| CHEMBL5183668 | — | — | 1 | 6.76 |
| CHEMBL5199914 | — | — | 1 | 6.75 |
| CHEMBL5198510 | — | — | 1 | 6.56 |
| CHEMBL5186645 | — | — | 1 | 6.18 |
| CHEMBL5179314 | — | — | 1 | - |
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | - |
| CHEMBL5203230 | — | — | 1 | - |
| CHEMBL5186714 | — | — | 1 | - |
| CHEMBL5170264 | — | — | 1 | - |
| CHEMBL5182360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177696 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5179582 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5187998 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5202912 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5191916 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5181688 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5202576 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5191744 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5178408 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5170820 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5179871 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5170945 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5204809 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5206740 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5186206 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5173348 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5183668 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5199914 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5198510 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL5186645 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL5179314 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3545376 | ERDAFITINIB | IC50 | - | — | - | |
| CHEMBL5203230 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5186714 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5170264 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5182360 | — | IC50 | > | 1000.0 | nM | - |