Assay Detail
Binding
CHEMBL5153633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR3 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.31 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 9.38 |
| CHEMBL5177696 | — | — | 1 | 9.34 |
| CHEMBL5181688 | — | — | 1 | 9.21 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5177696 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL5181688 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |