Assay Detail
Binding
CHEMBL5153775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine heart PDE1 using [3H]cGMP as substrate incubated for 10 mins by liquid scintillation counter analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Computational design, synthesis and biological evaluation of PDE5 inhibitors based on N<sup>2</sup>,N<sup>4</sup>-diaminoquinazoline and N<sup>2</sup>,N<sup>6</sup>-diaminopurine scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.93 | 4.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445920 | — | — | 1 | 4.93 |
| CHEMBL5194921 | — | — | 1 | - |
| CHEMBL5194783 | — | — | 1 | - |
| CHEMBL5184989 | — | — | 1 | - |
| CHEMBL5187496 | — | — | 1 | - |
| CHEMBL5175706 | — | — | 1 | - |
| CHEMBL5178863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445920 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL5194921 | — | IC50 | - | — | - | |
| CHEMBL5194783 | — | IC50 | - | — | - | |
| CHEMBL5184989 | — | IC50 | - | — | - | |
| CHEMBL5187496 | — | IC50 | - | — | - | |
| CHEMBL5175706 | — | IC50 | - | — | - | |
| CHEMBL5178863 | — | IC50 | - | — | - |