Assay Detail
Binding
CHEMBL5154107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation in the presence of an electron acceptor menadione
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type II NADH:quinone oxidoreductase Ndh (CHEMBL5169228) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201484 | — | — | 1 | 7.92 |
| CHEMBL5186518 | — | — | 1 | 7.92 |
| CHEMBL5171834 | — | — | 1 | 7.55 |
| CHEMBL5202255 | — | — | 1 | 7.50 |
| CHEMBL5206556 | — | — | 1 | 6.70 |
| CHEMBL5182198 | — | — | 1 | 6.47 |
| CHEMBL5196810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201484 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5186518 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5171834 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5202255 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5206556 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5182198 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5196810 | — | IC50 | - | — | - |