Assay Detail
Binding
CHEMBL5154189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse PDE9A expressed in recombinant CHO cells coexpressing soluble guanylate cyclase incubated for 6 mins by [3H]-cGMP scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL5169102) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.89 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198935 | — | — | 1 | 6.00 |
| CHEMBL2179105 | EDELINONTRINE | 2.0 | 1 | 5.77 |
| CHEMBL5181099 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198935 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2179105 | EDELINONTRINE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5181099 | — | EC50 | > | 10000.0 | nM | - |