Assay Detail
Functional
CHEMBL5154220
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Antiviral activity against SARS-CoV-2 infected in Vero E6 cells preincubated for 1 hr followed by methylcellulose addition and measured after 25 to 26 hrs by EliSpot reader based analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.88 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 6.42 |
| CHEMBL5174111 | — | — | 1 | 6.40 |
| CHEMBL5193842 | — | — | 1 | 5.86 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.64 |
| CHEMBL5206532 | — | — | 1 | 5.58 |
| CHEMBL5180502 | — | — | 1 | 5.37 |
| CHEMBL5190212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5174111 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5193842 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5206532 | — | EC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL5180502 | — | EC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL5190212 | — | EC50 | = | 183000.0 | nM | - |