Assay Detail
Functional
CHEMBL5154948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-COV 2 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication after 48 hrs by qRT-PCR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.02 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.16 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2016757 | GS-441524 | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 1350.0 | nM | 5.87 |