Assay Detail
Functional
CHEMBL5155033
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Antiviral activity against SARS-Cov-2 USA-WA1/2020 isolate infected in African green monkey Vero E6 cells measured after 48 hrs of postinfection by immunofluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.66 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207542 | — | — | 1 | 6.09 |
| CHEMBL5206501 | — | — | 1 | 5.90 |
| CHEMBL3427166 | — | — | 1 | 5.82 |
| CHEMBL5186431 | — | — | 1 | 5.79 |
| CHEMBL5189062 | — | — | 1 | 5.76 |
| CHEMBL5179577 | — | — | 1 | 5.69 |
| CHEMBL5201613 | — | — | 1 | 5.34 |
| CHEMBL5208393 | — | — | 1 | 4.88 |
| CHEMBL2311694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207542 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5206501 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3427166 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5186431 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5189062 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5179577 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5201613 | — | EC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL5208393 | — | EC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL2311694 | — | EC50 | > | 20000.0 | nM | - |