Assay Detail
Binding
CHEMBL5155034
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Non-covalent inhibition of SARS-Cov -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.33 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427166 | — | — | 1 | 7.46 |
| CHEMBL5206501 | — | — | 1 | 6.57 |
| CHEMBL2311694 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427166 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5206501 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2311694 | — | IC50 | = | 11230.0 | nM | 4.95 |