Assay Detail
Functional
CHEMBL5155123
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Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in plaque formation incubated for 48 hrs by crystal violet staining based plaque reduction assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.00 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191092 | — | — | 1 | 6.80 |
| CHEMBL5189954 | — | — | 1 | 6.55 |
| CHEMBL5191060 | — | — | 1 | 6.52 |
| CHEMBL5173658 | — | — | 1 | 6.33 |
| CHEMBL5191464 | — | — | 1 | 6.28 |
| CHEMBL5190213 | — | — | 1 | 6.22 |
| CHEMBL3427166 | — | — | 1 | 6.05 |
| CHEMBL5171263 | — | — | 1 | 5.55 |
| CHEMBL5195798 | — | — | 1 | 5.00 |
| CHEMBL5182169 | — | — | 1 | 4.67 |
| CHEMBL5187784 | — | — | 1 | - |
| CHEMBL5195086 | — | — | 1 | - |
| CHEMBL5192585 | — | — | 1 | - |
| CHEMBL5190876 | — | — | 1 | - |
| CHEMBL5193390 | — | — | 1 | - |
| CHEMBL5206120 | — | — | 1 | - |
| CHEMBL5198667 | — | — | 1 | - |
| CHEMBL5194822 | — | — | 1 | - |
| CHEMBL5179259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191092 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5189954 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5191060 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5173658 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5191464 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5190213 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3427166 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5171263 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5195798 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5182169 | — | EC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL5187784 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5195086 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5192585 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5190876 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5193390 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5206120 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5198667 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5194822 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5179259 | — | EC50 | > | 10000.0 | nM | - |