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Assay Detail

CHEMBL5155162

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Functional
Antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula assessed as phenotypic changes measured after 72 hrs
ChEMBL ↗
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Schistosoma mansoni
Confidence 1 — Organism
Curated By Autocuration

Target

Schistosoma mansoni (CHEMBL612893) ↗
Type ORGANISM
Organism Schistosoma mansoni

Publication

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF.
Eur J Med Chem (2021) 226 : 113823 -113823
PubMed 34536671 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 5.86 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5169441 — — 1 6.82
CHEMBL528789 — — 1 6.47
CHEMBL4440791 — — 1 6.47
CHEMBL5207588 — — 1 6.43
CHEMBL529407 — — 1 6.40
CHEMBL5183933 — — 1 6.38
CHEMBL5190370 — — 1 6.20
CHEMBL5173052 — — 1 6.11
CHEMBL5179153 — — 1 6.05
CHEMBL5176865 — — 1 5.99
CHEMBL976 PRAZIQUANTEL 4.0 1 5.94
CHEMBL5174302 — — 1 5.91
CHEMBL5173215 — — 1 5.91
CHEMBL528437 — — 1 5.86
CHEMBL5196931 — — 1 5.79
CHEMBL578491 — — 1 5.72
CHEMBL5183622 — — 1 5.72
CHEMBL3604526 — — 1 5.67
CHEMBL5183141 — — 1 5.66
CHEMBL5183012 — — 1 5.54
CHEMBL5172606 — — 1 5.52
CHEMBL5191101 — — 1 5.50
CHEMBL5187338 — — 1 5.46
CHEMBL537778 — — 1 5.43
CHEMBL5202919 — — 1 5.33
CHEMBL5176890 — — 1 5.29
CHEMBL5196834 — — 1 5.27
CHEMBL5171174 — — 1 5.23
CHEMBL5195068 — — 1 -
CHEMBL5202969 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5169441 — EC50 = 150.0 nM 6.82
CHEMBL528789 — EC50 = 340.0 nM 6.47
CHEMBL4440791 — EC50 = 340.0 nM 6.47
CHEMBL5207588 — EC50 = 370.0 nM 6.43
CHEMBL529407 — EC50 = 400.0 nM 6.40
CHEMBL5183933 — EC50 = 420.0 nM 6.38
CHEMBL5190370 — EC50 = 630.0 nM 6.20
CHEMBL5173052 — EC50 = 780.0 nM 6.11
CHEMBL5179153 — EC50 = 890.0 nM 6.05
CHEMBL5176865 — EC50 = 1020.0 nM 5.99
CHEMBL976 PRAZIQUANTEL EC50 = 1140.0 nM 5.94
CHEMBL5173215 — EC50 = 1220.0 nM 5.91
CHEMBL5174302 — EC50 = 1230.0 nM 5.91
CHEMBL528437 — EC50 = 1380.0 nM 5.86
CHEMBL5196931 — EC50 = 1620.0 nM 5.79
CHEMBL578491 — EC50 = 1890.0 nM 5.72
CHEMBL5183622 — EC50 = 1910.0 nM 5.72
CHEMBL3604526 — EC50 = 2140.0 nM 5.67
CHEMBL5183141 — EC50 = 2200.0 nM 5.66
CHEMBL5183012 — EC50 = 2880.0 nM 5.54
CHEMBL5172606 — EC50 = 3040.0 nM 5.52
CHEMBL5191101 — EC50 = 3190.0 nM 5.50
CHEMBL5187338 — EC50 = 3510.0 nM 5.46
CHEMBL537778 — EC50 = 3670.0 nM 5.43
CHEMBL5202919 — EC50 = 4720.0 nM 5.33
CHEMBL5176890 — EC50 = 5120.0 nM 5.29
CHEMBL5196834 — EC50 = 5420.0 nM 5.27
CHEMBL5171174 — EC50 = 5920.0 nM 5.23
CHEMBL5196654 — EC50 > 50000.0 nM -
CHEMBL5175727 — EC50 > 50000.0 nM -
CHEMBL5174618 — EC50 > 50000.0 nM -
CHEMBL3397267 — EC50 > 10000.0 nM -
CHEMBL5209226 — EC50 > 50000.0 nM -
CHEMBL5190101 — EC50 > 10000.0 nM -
CHEMBL5175177 — EC50 > 50000.0 nM -
CHEMBL5209102 — EC50 > 10000.0 nM -
CHEMBL5169397 — EC50 > 10000.0 nM -
CHEMBL23044 — EC50 > 50000.0 nM -
CHEMBL5186185 — EC50 > 50000.0 nM -
CHEMBL5173805 — EC50 > 50000.0 nM -
CHEMBL5202969 — EC50 > 10000.0 nM -
CHEMBL5195068 — EC50 > 10000.0 nM -