Assay Detail
Binding
CHEMBL5155326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.13 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541700 | GALLINAMIDE A | — | 1 | 8.13 |
| CHEMBL4594870 | — | — | 1 | - |
| CHEMBL4598338 | — | — | 1 | - |
| CHEMBL4594757 | — | — | 1 | - |
| CHEMBL4596647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541700 | GALLINAMIDE A | IC50 | = | 7.34 | nM | 8.13 |
| CHEMBL4594870 | — | IC50 | = | 2.78 | 10^-4microM | - |
| CHEMBL4598338 | — | IC50 | = | 4.76 | 10^-2microM | - |
| CHEMBL4594757 | — | IC50 | = | 4.16 | 10^-4microM | - |
| CHEMBL4596647 | — | IC50 | = | 1.49 | 10^-4microM | - |