Assay Detail
Functional
CHEMBL5155330
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral infection pre incubated for 30 minutes followed by viral infection and measured after 72 hrs by Nucblue dye based fluorometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594870 | — | — | 1 | 5.22 |
| CHEMBL541700 | GALLINAMIDE A | — | 1 | - |
| CHEMBL4598338 | — | — | 1 | - |
| CHEMBL4594757 | — | — | 1 | - |
| CHEMBL4596647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594870 | — | EC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL541700 | GALLINAMIDE A | EC50 | = | 2.8 | 10^-2microM | - |
| CHEMBL4598338 | — | EC50 | = | 1.68 | 10^-1microM | - |
| CHEMBL4594757 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4596647 | — | EC50 | = | 9.2 | 10^-1microM | - |