Assay Detail
Binding
CHEMBL5155335
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Inhibition of human recombinant Cathepsin B assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.43 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541700 | GALLINAMIDE A | — | 1 | 6.93 |
| CHEMBL4596647 | — | — | 1 | 6.62 |
| CHEMBL4598338 | — | — | 1 | 6.46 |
| CHEMBL4594870 | — | — | 1 | 6.07 |
| CHEMBL4594757 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541700 | GALLINAMIDE A | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL4596647 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL4598338 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL4594870 | — | Ki | = | 861.0 | nM | 6.07 |
| CHEMBL4594757 | — | Ki | = | 854.0 | nM | 6.07 |