Assay Detail
Binding
CHEMBL5155336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.07 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594757 | — | — | 1 | 8.40 |
| CHEMBL4596647 | — | — | 1 | 8.38 |
| CHEMBL541700 | GALLINAMIDE A | — | 1 | 8.28 |
| CHEMBL4598338 | — | — | 1 | 7.78 |
| CHEMBL4594870 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594757 | — | Ki | = | 3.95 | nM | 8.40 |
| CHEMBL4596647 | — | Ki | = | 4.15 | nM | 8.38 |
| CHEMBL541700 | GALLINAMIDE A | Ki | = | 5.29 | nM | 8.28 |
| CHEMBL4598338 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL4594870 | — | Ki | = | 29.3 | nM | 7.53 |