Assay Detail
Functional
CHEMBL5155474
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Antiproliferative activity against multi-drug resistant human A2780-DX cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780-DX |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.66 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191222 | — | — | 1 | 6.77 |
| CHEMBL5205518 | — | — | 1 | 6.51 |
| CHEMBL5207505 | — | — | 1 | 6.39 |
| CHEMBL5184014 | — | — | 1 | 6.18 |
| CHEMBL5209118 | — | — | 1 | 5.41 |
| CHEMBL5184608 | — | — | 1 | 5.38 |
| CHEMBL5190445 | — | — | 1 | 5.19 |
| CHEMBL5176182 | — | — | 1 | 4.62 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191222 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5205518 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5207505 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5184014 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5209118 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5184608 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5190445 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5176182 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 33000.0 | nM | 4.48 |