Assay Detail
Functional
CHEMBL5155486
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Antiproliferative activity against human MDA-MB-436 cells incubated for 24 hrs followed by incubating in drug-free medium for 48 hrs and measured by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-436 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.99 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191222 | — | — | 1 | 6.26 |
| CHEMBL5207505 | — | — | 1 | 6.19 |
| CHEMBL5184014 | — | — | 1 | 6.11 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191222 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5207505 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5184014 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3900.0 | nM | 5.41 |