Assay Detail
Binding
CHEMBL5155489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC11 (unknown origin) using fluorogenic peptide 382 RHKK(Ac)AM as substrate and measured by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.15 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207505 | — | — | 1 | 5.21 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.17 |
| CHEMBL5184014 | — | — | 1 | 5.08 |
| CHEMBL5191222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207505 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL5184014 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL5191222 | — | IC50 | > | 10000.0 | nM | - |