Assay Detail
Functional
CHEMBL5155583
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Antiplasmodial activity against CQ-susceptible Plasmodium falciparum 3D7 assessed as inhibition of parasite growth measured after 48 hrs by SYBR Green 1 dye based fluorescence assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 7.19 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178359 | — | — | 1 | 8.39 |
| CHEMBL5207890 | — | — | 1 | 7.94 |
| CHEMBL5183529 | — | — | 1 | 7.93 |
| CHEMBL5190838 | — | — | 1 | 7.84 |
| CHEMBL5183354 | — | — | 1 | 7.82 |
| CHEMBL5200928 | — | — | 1 | 7.76 |
| CHEMBL5174893 | — | — | 1 | 7.64 |
| CHEMBL5203709 | — | — | 1 | 7.62 |
| CHEMBL5183115 | — | — | 1 | 7.52 |
| CHEMBL5184272 | — | — | 1 | 7.51 |
| CHEMBL5180511 | — | — | 1 | 7.45 |
| CHEMBL5172366 | — | — | 1 | 7.45 |
| CHEMBL5173490 | — | — | 1 | 7.45 |
| CHEMBL5175462 | — | — | 1 | 7.44 |
| CHEMBL5172838 | — | — | 1 | 7.41 |
| CHEMBL5195793 | — | — | 1 | 7.35 |
| CHEMBL5198024 | — | — | 1 | 7.32 |
| CHEMBL5199777 | — | — | 1 | 7.27 |
| CHEMBL5208723 | — | — | 1 | 7.24 |
| CHEMBL5201658 | — | — | 1 | 7.16 |
| CHEMBL5193684 | — | — | 1 | 7.12 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.12 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.10 |
| CHEMBL5185062 | — | — | 1 | 7.03 |
| CHEMBL5197256 | — | — | 1 | 7.00 |
| CHEMBL5187624 | — | — | 1 | 6.99 |
| CHEMBL5197723 | — | — | 1 | 6.98 |
| CHEMBL5175580 | — | — | 1 | 6.87 |
| CHEMBL5172988 | — | — | 1 | 6.86 |
| CHEMBL5181490 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178359 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5207890 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5183529 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5190838 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5183354 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5200928 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5174893 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5203709 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL5183115 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL5184272 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL5180511 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL5172366 | — | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL5173490 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL5175462 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL5172838 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5195793 | — | IC50 | = | 45.1 | nM | 7.35 |
| CHEMBL5198024 | — | IC50 | = | 48.2 | nM | 7.32 |
| CHEMBL5199777 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL5208723 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL5201658 | — | IC50 | = | 68.5 | nM | 7.16 |
| CHEMBL5193684 | — | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 75.9 | nM | 7.12 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 79.7 | nM | 7.10 |
| CHEMBL5185062 | — | IC50 | = | 94.4 | nM | 7.03 |
| CHEMBL5197256 | — | IC50 | = | 99.3 | nM | 7.00 |
| CHEMBL5187624 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5197723 | — | IC50 | = | 103.9 | nM | 6.98 |
| CHEMBL5175580 | — | IC50 | = | 136.2 | nM | 6.87 |
| CHEMBL5172988 | — | IC50 | = | 138.4 | nM | 6.86 |
| CHEMBL5181490 | — | IC50 | = | 146.9 | nM | 6.83 |
| CHEMBL5181195 | — | IC50 | = | 166.4 | nM | 6.78 |
| CHEMBL5203779 | — | IC50 | = | 176.3 | nM | 6.75 |
| CHEMBL5177754 | — | IC50 | = | 248.7 | nM | 6.60 |
| CHEMBL5195831 | — | IC50 | = | 254.1 | nM | 6.59 |
| CHEMBL5201539 | — | IC50 | = | 361.1 | nM | 6.44 |
| CHEMBL5193724 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL5184619 | — | IC50 | = | 726.0 | nM | 6.14 |
| CHEMBL5181295 | — | IC50 | = | 953.1 | nM | 6.02 |
| CHEMBL5187052 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5171987 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5181138 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5189329 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5178016 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5179268 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5203532 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5200433 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5191385 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5204160 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5205263 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5174033 | — | IC50 | > | 1000.0 | nM | - |