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Assay Detail

CHEMBL5155584

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth measured after 48 hrs by SYBR Green 1 dye based fluorescence assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Dassonville-Klimpt A, Schneider J, Damiani C, Tisnerat C, Cohen A, Azas N, Marchivie M, Guillon J, Mullié C, Agnamey P, Totet A, Dormoi J, Taudon N, Pradines B, Sonnet P.
Eur J Med Chem (2022) 228 : 113981 -113981
PubMed 34782182 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 7.39 8.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5184272 1 8.48
CHEMBL5178359 1 8.39
CHEMBL5190838 1 8.29
CHEMBL5183115 1 8.25
CHEMBL5207890 1 8.07
CHEMBL5185062 1 8.01
CHEMBL5187624 1 8.00
CHEMBL5198024 1 8.00
CHEMBL5201658 1 8.00
CHEMBL5180511 1 7.99
CHEMBL5200928 1 7.94
CHEMBL5183354 1 7.88
CHEMBL5197723 1 7.80
CHEMBL5174893 1 7.78
CHEMBL5199777 1 7.53
CHEMBL5172366 1 7.53
CHEMBL5175580 1 7.52
CHEMBL172 (S,R)-MEFLOQUINE 1 7.50
CHEMBL5197256 1 7.50
CHEMBL5173490 1 7.47
CHEMBL5172838 1 7.43
CHEMBL5203709 1 7.36
CHEMBL5172988 1 7.29
CHEMBL5175462 1 7.26
CHEMBL5183529 1 7.24
CHEMBL5201539 1 7.21
CHEMBL5208723 1 7.21
CHEMBL5193684 1 7.20
CHEMBL5195793 1 7.12
CHEMBL5195831 1 6.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5184272 IC50 = 3.3 nM 8.48
CHEMBL5178359 IC50 = 4.1 nM 8.39
CHEMBL5190838 IC50 = 5.1 nM 8.29
CHEMBL5183115 IC50 = 5.6 nM 8.25
CHEMBL5207890 IC50 = 8.55 nM 8.07
CHEMBL5185062 IC50 = 9.8 nM 8.01
CHEMBL5187624 IC50 = 10.1 nM 8.00
CHEMBL5198024 IC50 = 10.1 nM 8.00
CHEMBL5201658 IC50 = 10.0 nM 8.00
CHEMBL5180511 IC50 = 10.3 nM 7.99
CHEMBL5200928 IC50 = 11.4 nM 7.94
CHEMBL5183354 IC50 = 13.2 nM 7.88
CHEMBL5197723 IC50 = 15.9 nM 7.80
CHEMBL5174893 IC50 = 16.8 nM 7.78
CHEMBL5172366 IC50 = 29.6 nM 7.53
CHEMBL5199777 IC50 = 29.3 nM 7.53
CHEMBL5175580 IC50 = 29.9 nM 7.52
CHEMBL172 (S,R)-MEFLOQUINE IC50 = 31.8 nM 7.50
CHEMBL5197256 IC50 = 31.5 nM 7.50
CHEMBL5173490 IC50 = 34.0 nM 7.47
CHEMBL5172838 IC50 = 36.7 nM 7.43
CHEMBL5203709 IC50 = 43.8 nM 7.36
CHEMBL5172988 IC50 = 51.7 nM 7.29
CHEMBL5175462 IC50 = 54.3 nM 7.26
CHEMBL5183529 IC50 = 57.2 nM 7.24
CHEMBL5201539 IC50 = 61.8 nM 7.21
CHEMBL5208723 IC50 = 61.0 nM 7.21
CHEMBL5193684 IC50 = 63.0 nM 7.20
CHEMBL5195793 IC50 = 76.5 nM 7.12
CHEMBL5195831 IC50 = 136.9 nM 6.86
CHEMBL5193724 IC50 = 182.0 nM 6.74
CHEMBL76 CHLOROQUINE IC50 = 198.8 nM 6.70
CHEMBL5178016 IC50 = 321.0 nM 6.49
CHEMBL5203779 IC50 = 379.2 nM 6.42
CHEMBL5179268 IC50 = 534.0 nM 6.27
CHEMBL5181295 IC50 = 707.1 nM 6.15
CHEMBL5177754 IC50 = 837.1 nM 6.08
CHEMBL5177110 IC50 = 1459.0 nM 5.84
CHEMBL5200433 IC50 - -
CHEMBL5191385 IC50 - -
CHEMBL5204160 IC50 - -
CHEMBL5205263 IC50 - -
CHEMBL5174033 IC50 - -
CHEMBL5180639 IC50 - -
CHEMBL5189329 IC50 > 1000.0 nM -
CHEMBL5181138 IC50 > 1000.0 nM -
CHEMBL5201301 IC50 > 1000.0 nM -
CHEMBL5181490 IC50 > 1000.0 nM -
CHEMBL5203532 IC50 > 1000.0 nM -
CHEMBL5184619 IC50 - -