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Assay Detail

CHEMBL5155589

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type HFF
Confidence 1 — Organism
Curated By Autocuration

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Dassonville-Klimpt A, Schneider J, Damiani C, Tisnerat C, Cohen A, Azas N, Marchivie M, Guillon J, Mullié C, Agnamey P, Totet A, Dormoi J, Taudon N, Pradines B, Sonnet P.
Eur J Med Chem (2022) 228 : 113981 -113981
PubMed 34782182 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.55 4.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5193684 1 4.88
CHEMBL5195793 1 4.86
CHEMBL5208723 1 4.84
CHEMBL5172366 1 4.78
CHEMBL5178359 1 4.73
CHEMBL5183115 1 4.59
CHEMBL5207890 1 4.45
CHEMBL5175462 1 4.43
CHEMBL5200928 1 4.43
CHEMBL5183354 1 4.36
CHEMBL5173490 1 4.36
CHEMBL5180511 1 4.34
CHEMBL5174893 1 4.32
CHEMBL5184272 1 4.27
CHEMBL53463 DOXORUBICIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5193684 IC50 = 13300.0 nM 4.88
CHEMBL5195793 IC50 = 13900.0 nM 4.86
CHEMBL5208723 IC50 = 14600.0 nM 4.84
CHEMBL5172366 IC50 = 16600.0 nM 4.78
CHEMBL5178359 IC50 = 18500.0 nM 4.73
CHEMBL5183115 IC50 = 25400.0 nM 4.59
CHEMBL5207890 IC50 = 35600.0 nM 4.45
CHEMBL5175462 IC50 = 37350.0 nM 4.43
CHEMBL5200928 IC50 = 36700.0 nM 4.43
CHEMBL5183354 IC50 = 44200.0 nM 4.36
CHEMBL5173490 IC50 = 43900.0 nM 4.36
CHEMBL5180511 IC50 = 45400.0 nM 4.34
CHEMBL5174893 IC50 = 48400.0 nM 4.32
CHEMBL5184272 IC50 = 53700.0 nM 4.27
CHEMBL53463 DOXORUBICIN IC50 - -