Assay Detail
Toxicity
CHEMBL5155596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.99 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177406 | — | — | 1 | 5.25 |
| CHEMBL5204309 | — | — | 1 | 5.16 |
| CHEMBL5181317 | — | — | 1 | 5.06 |
| CHEMBL411329 | (R,S)-MEFLOQUINE | — | 1 | 4.87 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 4.82 |
| CHEMBL5183354 | — | — | 1 | 4.76 |
| CHEMBL5191501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177406 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5204309 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5181317 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL411329 | (R,S)-MEFLOQUINE | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5183354 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5191501 | — | IC50 | > | 30000.0 | nM | - |