Assay Detail
Functional
CHEMBL5155647
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Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.77 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206531 | — | — | 1 | 8.20 |
| CHEMBL5204855 | — | — | 1 | 7.44 |
| CHEMBL5199288 | — | — | 1 | 7.29 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.87 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.07 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206531 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5204855 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL5199288 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 8571.0 | nM | 5.07 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | - | — | - |