Assay Detail
Functional
CHEMBL5155649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.15 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206531 | — | — | 1 | 8.11 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.99 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.96 |
| CHEMBL5199288 | — | — | 1 | 6.86 |
| CHEMBL5204855 | — | — | 1 | 6.84 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206531 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL107 | COLCHICINE | IC50 | = | 101.8 | nM | 6.99 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 108.4 | nM | 6.96 |
| CHEMBL5199288 | — | IC50 | = | 136.8 | nM | 6.86 |
| CHEMBL5204855 | — | IC50 | = | 143.9 | nM | 6.84 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - |