Assay Detail
Functional
CHEMBL5155960
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Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A<sub>3</sub> adenosine receptor agonists containing dopamine moieties for enhanced interspecies affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.18 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170037 | — | — | 1 | 7.62 |
| CHEMBL5178814 | — | — | 1 | 7.50 |
| CHEMBL5196916 | — | — | 1 | 7.46 |
| CHEMBL5181821 | — | — | 1 | 7.42 |
| CHEMBL5190575 | — | — | 1 | 7.36 |
| CHEMBL5202349 | — | — | 1 | 7.34 |
| CHEMBL5175945 | — | — | 1 | 7.31 |
| CHEMBL5203255 | — | — | 1 | 7.19 |
| CHEMBL5195772 | — | — | 1 | 7.18 |
| CHEMBL464859 | NECA | — | 1 | 6.81 |
| CHEMBL5174613 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170037 | — | EC50 | = | 23.7 | nM | 7.62 |
| CHEMBL5178814 | — | EC50 | = | 31.3 | nM | 7.50 |
| CHEMBL5196916 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5181821 | — | EC50 | = | 38.5 | nM | 7.42 |
| CHEMBL5190575 | — | EC50 | = | 43.9 | nM | 7.36 |
| CHEMBL5202349 | — | EC50 | = | 45.9 | nM | 7.34 |
| CHEMBL5175945 | — | EC50 | = | 49.4 | nM | 7.31 |
| CHEMBL5203255 | — | EC50 | = | 64.9 | nM | 7.19 |
| CHEMBL5195772 | — | EC50 | = | 66.4 | nM | 7.18 |
| CHEMBL464859 | NECA | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5174613 | — | EC50 | = | 1430.0 | nM | 5.84 |