Assay Detail
Functional
CHEMBL5156385
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Antiproliferative activity against human TMD8 cells incubated for 72 hrs by luminescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.42 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182870 | — | — | 1 | 6.51 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182870 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 480.0 | nM | 6.32 |