Assay Detail
Binding
CHEMBL5156508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.20 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 8.38 |
| CHEMBL1997924 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 4.19 | nM | 8.38 |
| CHEMBL1997924 | — | IC50 | = | 9.47 | nM | 8.02 |