Assay Detail
Functional
CHEMBL5156557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LNCaP C4-2B cells assessed as inhibition of cell growth by Celltiter-Glo assay
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.85 | 5.78 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 5.78 |
| CHEMBL5204688 | — | — | 1 | 5.53 |
| CHEMBL3814752 | — | — | 1 | 5.47 |
| CHEMBL5191045 | — | — | 1 | 5.30 |
| CHEMBL5179520 | — | — | 1 | 5.19 |
| CHEMBL5179809 | — | — | 1 | 5.06 |
| CHEMBL5208356 | — | — | 1 | 5.04 |
| CHEMBL5207470 | — | — | 1 | 5.03 |
| CHEMBL5198394 | — | — | 1 | 5.02 |
| CHEMBL5204233 | — | — | 1 | 4.87 |
| CHEMBL5195756 | — | — | 1 | 4.76 |
| CHEMBL5198835 | — | — | 1 | 4.54 |
| CHEMBL5200678 | — | — | 1 | 4.53 |
| CHEMBL5185538 | — | — | 1 | 4.47 |
| CHEMBL5192405 | — | — | 1 | 4.47 |
| CHEMBL5181127 | — | — | 1 | 4.46 |
| CHEMBL5201144 | — | — | 1 | 4.43 |
| CHEMBL5192554 | — | — | 1 | 4.38 |
| CHEMBL5195875 | — | — | 1 | 4.30 |
| CHEMBL5202460 | — | — | 1 | 4.30 |
| CHEMBL5192803 | — | — | 1 | - |
| CHEMBL5205974 | — | — | 1 | - |
| CHEMBL4171749 | — | — | 1 | - |
| CHEMBL5174255 | — | — | 1 | - |
| CHEMBL5193196 | — | — | 1 | - |
| CHEMBL5179328 | — | — | 1 | - |
| CHEMBL5179738 | — | — | 1 | - |
| CHEMBL5191527 | — | — | 1 | - |
| CHEMBL5196089 | — | — | 1 | - |
| CHEMBL5189533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5204688 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3814752 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL5191045 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5179520 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL5179809 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL5208356 | — | IC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL5207470 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL5198394 | — | IC50 | = | 9570.0 | nM | 5.02 |
| CHEMBL5204233 | — | IC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL5195756 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL5198835 | — | IC50 | = | 29030.0 | nM | 4.54 |
| CHEMBL5200678 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL5185538 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL5192405 | — | IC50 | = | 34180.0 | nM | 4.47 |
| CHEMBL5181127 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL5201144 | — | IC50 | = | 36990.0 | nM | 4.43 |
| CHEMBL5192554 | — | IC50 | = | 42040.0 | nM | 4.38 |
| CHEMBL5195875 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5202460 | — | IC50 | = | 49690.0 | nM | 4.30 |
| CHEMBL5192803 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5205974 | — | Activity | - | — | - | |
| CHEMBL4171749 | — | Activity | - | — | - | |
| CHEMBL5174255 | — | Activity | - | — | - | |
| CHEMBL5193196 | — | Activity | - | — | - | |
| CHEMBL5179328 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5179738 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5191527 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5196089 | — | Activity | - | — | - | |
| CHEMBL5189533 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5208083 | — | IC50 | > | 50000.0 | nM | - |