Assay Detail
Functional
CHEMBL5156610
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Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition by Celltiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.74 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 6.38 |
| CHEMBL5179520 | — | — | 1 | 5.69 |
| CHEMBL5191045 | — | — | 1 | 5.62 |
| CHEMBL5204688 | — | — | 1 | 5.53 |
| CHEMBL3814752 | — | — | 1 | 5.50 |
| CHEMBL5192803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5179520 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5191045 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL5204688 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL3814752 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5192803 | — | IC50 | > | 5000.0 | nM | - |