Assay Detail
Binding
CHEMBL5156637
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Inhibition of Mycobacterium smegmatis ATP synthase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | 8.00 |
| CHEMBL5203600 | — | — | 1 | 6.11 |
| CHEMBL5174922 | — | — | 1 | 6.05 |
| CHEMBL5182845 | — | — | 1 | 6.00 |
| CHEMBL5187469 | — | — | 1 | 5.88 |
| CHEMBL5197612 | — | — | 1 | 5.82 |
| CHEMBL5184496 | — | — | 1 | 5.72 |
| CHEMBL5184741 | — | — | 1 | 5.72 |
| CHEMBL5189654 | — | — | 1 | 5.70 |
| CHEMBL5201444 | — | — | 1 | 5.66 |
| CHEMBL5201354 | — | — | 1 | 5.64 |
| CHEMBL5200450 | — | — | 1 | 5.62 |
| CHEMBL5191368 | — | — | 1 | 5.62 |
| CHEMBL5194550 | — | — | 1 | 5.57 |
| CHEMBL5178938 | — | — | 1 | 5.55 |
| CHEMBL5190666 | — | — | 1 | 5.43 |
| CHEMBL5189460 | — | — | 1 | 5.39 |
| CHEMBL5189782 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5203600 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5174922 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5182845 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5187469 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5197612 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5184496 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5184741 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5189654 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5201444 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL5201354 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5200450 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5191368 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5194550 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5178938 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL5190666 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL5189460 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL5189782 | — | IC50 | = | 4600.0 | nM | 5.34 |