Assay Detail
Binding
CHEMBL5157482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAO-A (unknown origin) expressed in mouse GL26 cells using 14C 5-hydroxytryptamine as substrate pre-incubated for 20 mins followed by substrate addition measured after 20 mins by liquid scintillation spectroscopy
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | GL26 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
<i>N</i>-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.31 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178014 | — | — | 1 | 9.40 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 9.00 |
| CHEMBL5191350 | — | — | 1 | 8.40 |
| CHEMBL5187984 | — | — | 1 | 7.70 |
| CHEMBL5182215 | — | — | 1 | 7.52 |
| CHEMBL5177240 | — | — | 1 | 6.37 |
| CHEMBL5170598 | — | — | 1 | 5.49 |
| CHEMBL5193384 | — | — | 1 | 4.63 |
| CHEMBL5200566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178014 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5191350 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5187984 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5182215 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5177240 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5170598 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5193384 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL5200566 | — | IC50 | < | 0.1 | nM | - |