Assay Detail
Binding
CHEMBL5157484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC2 (379 to 382 residues) using RHKKAc-AMC fluorogenic peptide as substrate by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
<i>N</i>-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.74 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170598 | — | — | 1 | 6.82 |
| CHEMBL5182215 | — | — | 1 | 6.34 |
| CHEMBL5191350 | — | — | 1 | 5.94 |
| CHEMBL5193384 | — | — | 1 | 5.49 |
| CHEMBL5200566 | — | — | 1 | 5.44 |
| CHEMBL5187984 | — | — | 1 | 5.38 |
| CHEMBL5178014 | — | — | 1 | 5.32 |
| CHEMBL5177240 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170598 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5182215 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5191350 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5193384 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5200566 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL5187984 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL5178014 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5177240 | — | IC50 | = | 6680.0 | nM | 5.17 |