Assay Detail
Binding
CHEMBL5157486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC8 (379 to 382 residues) using RHKKAcKAc-AMC fluorogenic peptide as substrate by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
<i>N</i>-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.24 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170598 | — | — | 1 | 7.30 |
| CHEMBL5191350 | — | — | 1 | 7.10 |
| CHEMBL5182215 | — | — | 1 | 6.48 |
| CHEMBL5187984 | — | — | 1 | 5.95 |
| CHEMBL5178014 | — | — | 1 | 5.93 |
| CHEMBL5193384 | — | — | 1 | 5.83 |
| CHEMBL5177240 | — | — | 1 | 5.75 |
| CHEMBL5200566 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170598 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5191350 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5182215 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5187984 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5178014 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5193384 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5177240 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5200566 | — | IC50 | = | 2480.0 | nM | 5.61 |