Assay Detail
Binding
CHEMBL5157487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LSD1 assessed as demethylase activity of LSD1 using Histone H3(1-21)K4me2 peptide as substrate incubated for 30 mins followed by substrate addition by amplex red dye based HRP-coupled assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
<i>N</i>-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 2 | 5.11 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178014 | — | — | 1 | 5.22 |
| CHEMBL5191350 | — | — | 1 | 5.00 |
| CHEMBL5182215 | — | — | 1 | - |
| CHEMBL5200566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178014 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5191350 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5182215 | — | Activity | - | — | - | |
| CHEMBL5200566 | — | Activity | - | — | - |