Assay Detail
Functional
CHEMBL5157489
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Cytotoxicity against human TMZ-resistant U251 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
<i>N</i>-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.44 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170598 | — | — | 1 | 6.22 |
| CHEMBL5191350 | — | — | 1 | 6.00 |
| CHEMBL5182215 | — | — | 1 | 5.56 |
| CHEMBL5193384 | — | — | 1 | 5.39 |
| CHEMBL5187984 | — | — | 1 | 5.32 |
| CHEMBL5178014 | — | — | 1 | 5.15 |
| CHEMBL5177240 | — | — | 1 | 5.06 |
| CHEMBL5200566 | — | — | 1 | 4.79 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170598 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5191350 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5182215 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5193384 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL5187984 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL5178014 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL5177240 | — | IC50 | = | 8670.0 | nM | 5.06 |
| CHEMBL5200566 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | = | 136000.0 | nM | - |