Assay Detail
Binding
CHEMBL5157824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at pBIND tagged human PPARdelta expressed in human HepG2 cells incubated for 18 hrs by dual luciferase reporter assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 5.91 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38508 | — | — | 1 | 8.00 |
| CHEMBL5205109 | — | — | 1 | 6.77 |
| CHEMBL5173019 | — | — | 1 | 6.57 |
| CHEMBL5178528 | — | — | 1 | 6.44 |
| CHEMBL5192621 | — | — | 1 | 6.41 |
| CHEMBL5196452 | — | — | 1 | 6.35 |
| CHEMBL5186275 | — | — | 1 | 6.32 |
| CHEMBL5183783 | — | — | 1 | 6.27 |
| CHEMBL5191306 | — | — | 1 | 6.06 |
| CHEMBL5208111 | — | — | 1 | 5.79 |
| CHEMBL5173326 | — | — | 1 | 5.75 |
| CHEMBL5181439 | — | — | 1 | 5.71 |
| CHEMBL5190883 | — | — | 1 | 5.67 |
| CHEMBL5171641 | — | — | 1 | 5.54 |
| CHEMBL5187322 | — | — | 1 | 5.53 |
| CHEMBL5199948 | — | — | 1 | 5.51 |
| CHEMBL5186963 | — | — | 1 | 5.49 |
| CHEMBL5184830 | — | — | 1 | 5.49 |
| CHEMBL5175597 | — | — | 1 | 5.44 |
| CHEMBL5200197 | — | — | 1 | 5.42 |
| CHEMBL5176157 | — | — | 1 | 5.37 |
| CHEMBL5203672 | — | — | 1 | 5.35 |
| CHEMBL5194153 | — | — | 1 | 5.33 |
| CHEMBL5175750 | — | — | 1 | 5.32 |
| CHEMBL5175124 | — | — | 1 | - |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | - |
| CHEMBL21241 | GW7647 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38508 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5205109 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5173019 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5178528 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5192621 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5196452 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5186275 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5183783 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5191306 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5208111 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5173326 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5181439 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5190883 | — | EC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5171641 | — | EC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL5187322 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL5199948 | — | EC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL5186963 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5184830 | — | EC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL5175597 | — | EC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL5200197 | — | EC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL5176157 | — | EC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5203672 | — | EC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5194153 | — | EC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL5175750 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5175124 | — | EC50 | - | — | - | |
| CHEMBL121 | ROSIGLITAZONE | EC50 | - | — | - | |
| CHEMBL21241 | GW7647 | EC50 | - | — | - |