Assay Detail
Binding
CHEMBL5157973
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Stabilization of Red-dye-NHS fluorescent-labeled human LDH-Htr expressed in Escherichia coli assessed as dissociation constant by MST assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.27 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21731 | MAPROTILINE | 4.0 | 1 | 4.43 |
| CHEMBL855 | TRIPROLIDINE | 4.0 | 1 | 4.10 |
| CHEMBL3183133 | — | — | 1 | - |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | - |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21731 | MAPROTILINE | Kd | = | 37000.0 | nM | 4.43 |
| CHEMBL855 | TRIPROLIDINE | Kd | = | 79000.0 | nM | 4.10 |
| CHEMBL3183133 | — | Kd | = | 183000.0 | nM | - |
| CHEMBL898 | DIFLUNISAL | Kd | = | 1000000.0 | nM | - |
| CHEMBL23588 | FLUFENAMIC ACID | Kd | = | 900000.0 | nM | - |