Assay Detail
Binding
CHEMBL5158074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant NEK1 (1 to 505 residues) using ULight-p70 S6K peptide as substrate incubated for 30 mins by LANCE Ultra TR-FRET assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Nek1 (CHEMBL5855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.43 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201686 | — | — | 1 | 6.48 |
| CHEMBL5206874 | — | — | 1 | 6.00 |
| CHEMBL5189609 | — | — | 1 | 5.89 |
| CHEMBL5200819 | — | — | 1 | 5.80 |
| CHEMBL5174141 | — | — | 1 | 5.72 |
| CHEMBL5182208 | — | — | 1 | 5.70 |
| CHEMBL5182549 | — | — | 1 | 5.57 |
| CHEMBL5197597 | — | — | 1 | 5.50 |
| CHEMBL5203616 | — | — | 1 | 5.24 |
| CHEMBL5208840 | — | — | 1 | 5.18 |
| CHEMBL520954 | — | — | 1 | 5.15 |
| CHEMBL5197360 | — | — | 1 | 5.06 |
| CHEMBL5181887 | — | — | 1 | 5.00 |
| CHEMBL5197075 | — | — | 1 | 4.57 |
| CHEMBL5180286 | — | — | 1 | 4.54 |
| CHEMBL5198653 | — | — | 1 | - |
| CHEMBL5180705 | — | — | 1 | - |
| CHEMBL5172286 | — | — | 1 | - |
| CHEMBL5175782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201686 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5206874 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5189609 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5200819 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5174141 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5182208 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5182549 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5197597 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5203616 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5208840 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL520954 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5197360 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5181887 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5197075 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5180286 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5198653 | — | IC50 | - | — | - | |
| CHEMBL5180705 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5172286 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5175782 | — | IC50 | - | — | - |