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Assay Detail

CHEMBL5158216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor alpha (CHEMBL239)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
Sahin C, Magomedova L, Ferreira TAM, Liu J, Tiefenbach J, Alves PS, Queiroz FJG, Oliveira AS, Bhattacharyya M, Grouleff J, Nogueira PCN, Silveira ER, Moreira DC, Leite JRSA, Brand GD, Uehling D, Poda G, Krause H, Cummins CL, Romeiro LAS.
J Med Chem (2022) 65 : 1961 -1978
PubMed 35089724 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 5.28 8.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL21241 GW7647 1 8.19
CHEMBL5187974 1 6.30
CHEMBL5191280 1 6.16
CHEMBL5198240 1 5.96
CHEMBL5177968 1 5.62
CHEMBL5182467 1 5.46
CHEMBL33778 ANACARDIC ACID 1 5.46
CHEMBL5191595 1 5.36
CHEMBL4800442 1 5.05
CHEMBL5198233 1 5.05
CHEMBL111077 MYRISTIC ACID -1.0 1 4.89
CHEMBL5173082 1 4.77
CHEMBL5196042 1 4.68
CHEMBL107498 DECANOIC ACID 1 4.51
CHEMBL30915 1 4.50
CHEMBL8659 OLEIC ACID 2.0 1 4.44
CHEMBL46403 STEARIC ACID -1.0 1 4.40
CHEMBL5192854 1 4.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL21241 GW7647 EC50 = 6.5 nM 8.19
CHEMBL5187974 EC50 = 500.0 nM 6.30
CHEMBL5191280 EC50 = 700.0 nM 6.16
CHEMBL5198240 EC50 = 1100.0 nM 5.96
CHEMBL5177968 EC50 = 2400.0 nM 5.62
CHEMBL5182467 EC50 = 3500.0 nM 5.46
CHEMBL33778 ANACARDIC ACID EC50 = 3500.0 nM 5.46
CHEMBL5191595 EC50 = 4400.0 nM 5.36
CHEMBL4800442 EC50 = 8900.0 nM 5.05
CHEMBL5198233 EC50 = 8900.0 nM 5.05
CHEMBL111077 MYRISTIC ACID EC50 = 13000.0 nM 4.89
CHEMBL5173082 EC50 = 17000.0 nM 4.77
CHEMBL5196042 EC50 = 21000.0 nM 4.68
CHEMBL107498 DECANOIC ACID EC50 = 31000.0 nM 4.51
CHEMBL30915 EC50 = 32000.0 nM 4.50
CHEMBL8659 OLEIC ACID EC50 = 36000.0 nM 4.44
CHEMBL46403 STEARIC ACID EC50 = 40000.0 nM 4.40
CHEMBL5192854 EC50 = 67000.0 nM 4.17