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Assay Detail

CHEMBL5158325

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GSK3beta (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators.
Wesseler F, Riege D, Puthanveedu M, Halver J, Müller E, Bertrand J, Antonchick AP, Sievers S, Waldmann H, Schade D.
J Med Chem (2022) 65 : 3978 -3990
PubMed 35108017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4639853 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4639853 IC50 = 2.0 nM 8.70