Assay Detail
Functional
CHEMBL5158342
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Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of HDAC6-Selective Inhibitor NN-390 with <i>in Vitro</i> Efficacy in Group 3 Medulloblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.87 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.54 |
| CHEMBL5192865 | — | — | 1 | 6.40 |
| CHEMBL5179295 | — | — | 1 | 6.29 |
| CHEMBL5202595 | — | — | 1 | 6.28 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 6.18 |
| CHEMBL5191960 | — | — | 1 | 6.18 |
| CHEMBL5202970 | — | — | 1 | 6.05 |
| CHEMBL5195141 | — | — | 1 | 6.00 |
| CHEMBL5177475 | — | — | 1 | 5.92 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 5.91 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.78 |
| CHEMBL5184540 | — | — | 1 | 5.60 |
| CHEMBL5199669 | — | — | 1 | 5.57 |
| CHEMBL5208971 | — | — | 1 | 5.25 |
| CHEMBL5173782 | — | — | 1 | 5.13 |
| CHEMBL4763401 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5192865 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5179295 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5202595 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL5191960 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5202970 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5195141 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5177475 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5184540 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5199669 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL5208971 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL5173782 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL4763401 | — | IC50 | = | 16400.0 | nM | 4.79 |