Assay Detail
Binding
CHEMBL5158348
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Binding affinity to full length human recombinant HDAC6 expressed in Sf9 baculovirus system assessed as inhibition constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of HDAC6-Selective Inhibitor NN-390 with <i>in Vitro</i> Efficacy in Group 3 Medulloblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.08 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177475 | — | — | 1 | 8.39 |
| CHEMBL5192865 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177475 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL5192865 | — | Ki | = | 17.3 | nM | 7.76 |