Assay Detail
Toxicity
CHEMBL5158357
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Cytotoxicity against human fetal neuronal stem cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | NSC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of HDAC6-Selective Inhibitor NN-390 with <i>in Vitro</i> Efficacy in Group 3 Medulloblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.48 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192865 | — | — | 1 | 5.84 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 5.36 |
| CHEMBL5177475 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192865 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL5177475 | — | IC50 | = | 5760.0 | nM | 5.24 |