Assay Detail
Toxicity
CHEMBL5158359
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Cytotoxicity against HUVEC cells assessed as inhibition of cell growth incubated for 72 hrs measured by spectrophotometer analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of HDAC6-Selective Inhibitor NN-390 with <i>in Vitro</i> Efficacy in Group 3 Medulloblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179295 | — | — | 1 | 5.43 |
| CHEMBL5192865 | — | — | 1 | 5.41 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 5.31 |
| CHEMBL5177475 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179295 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5192865 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5177475 | — | IC50 | = | 10100.0 | nM | 5.00 |