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Assay Detail

CHEMBL5158769

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bacterial IMP-1 using CDC-1 as substrate incubated for 30 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacteria
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases.
Hu L, Yang H, Yu T, Chen F, Liu R, Xue S, Zhang S, Mao W, Ji C, Wang H, Xie H.
Eur J Med Chem (2022) 232 : 114174 -114174
PubMed 35152091 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.11 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5194932 1 6.10
CHEMBL5183074 1 5.34
CHEMBL5182259 1 5.26
CHEMBL5197006 1 5.18
CHEMBL5182042 1 5.13
CHEMBL5193687 1 5.10
CHEMBL5177073 1 5.10
CHEMBL5188069 1 5.08
CHEMBL5185452 1 5.06
CHEMBL5200653 1 4.82
CHEMBL5203817 1 4.82
CHEMBL5178017 1 4.80
CHEMBL5172396 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5194932 IC50 = 800.0 nM 6.10
CHEMBL5183074 IC50 = 4600.0 nM 5.34
CHEMBL5182259 IC50 = 5500.0 nM 5.26
CHEMBL5197006 IC50 = 6600.0 nM 5.18
CHEMBL5182042 IC50 = 7400.0 nM 5.13
CHEMBL5193687 IC50 = 8000.0 nM 5.10
CHEMBL5177073 IC50 = 7900.0 nM 5.10
CHEMBL5188069 IC50 = 8400.0 nM 5.08
CHEMBL5185452 IC50 = 8800.0 nM 5.06
CHEMBL5200653 IC50 = 15000.0 nM 4.82
CHEMBL5203817 IC50 = 15000.0 nM 4.82
CHEMBL5178017 IC50 = 16000.0 nM 4.80
CHEMBL5172396 IC50 = 20000.0 nM 4.70