Assay Detail
Binding
CHEMBL5159013
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Inhibition of AURC (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482767 | SNS-314 | 1.0 | 1 | 8.52 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.34 |
| CHEMBL1090479 | GSK-1070916 | 1.0 | 1 | 8.19 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482767 | SNS-314 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1090479 | GSK-1070916 | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 61.0 | nM | 7.21 |