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Assay Detail

CHEMBL5159114

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania major (MHOM/IL/80/Friedlin) promastigotes assessed as reduction in parasite growth incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania major
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania major (CHEMBL612879)
Type ORGANISM
Organism Leishmania major

Publication

Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity.
Belmonte-Reche E, Benassi A, Peñalver P, Cucchiarini A, Guédin A, Mergny JL, Rosu F, Gabelica V, Freccero M, Doria F, Morales JC.
Eur J Med Chem (2022) 232 : 114183 -114183
PubMed 35168151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.46 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4095443 1 6.52
CHEMBL5195378 1 6.29
CHEMBL5174664 1 6.13
CHEMBL5170475 1 6.10
CHEMBL4068055 1 6.10
CHEMBL5207677 1 5.86
CHEMBL5198659 1 5.82
CHEMBL5187011 1 4.98
CHEMBL5172848 1 4.86
CHEMBL5183131 1 4.66
CHEMBL5183586 1 4.56
CHEMBL5173053 1 4.52
CHEMBL5180970 1 4.52
CHEMBL5193069 1 -
CHEMBL5199159 1 -
CHEMBL5172630 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4095443 IC50 = 300.0 nM 6.52
CHEMBL5195378 IC50 = 510.0 nM 6.29
CHEMBL5174664 IC50 = 740.0 nM 6.13
CHEMBL5170475 IC50 = 800.0 nM 6.10
CHEMBL4068055 IC50 = 790.0 nM 6.10
CHEMBL5207677 IC50 = 1380.0 nM 5.86
CHEMBL5198659 IC50 = 1520.0 nM 5.82
CHEMBL5187011 IC50 = 10500.0 nM 4.98
CHEMBL5172848 IC50 = 13900.0 nM 4.86
CHEMBL5183131 IC50 = 21700.0 nM 4.66
CHEMBL5183586 IC50 = 27500.0 nM 4.56
CHEMBL5173053 IC50 = 30200.0 nM 4.52
CHEMBL5180970 IC50 = 30000.0 nM 4.52
CHEMBL5193069 IC50 > 50000.0 nM -
CHEMBL5199159 IC50 > 50000.0 nM -
CHEMBL5172630 IC50 > 50000.0 nM -