Assay Detail
Binding
CHEMBL5159176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum HGXPRT using PRib-PP as substrate by spectrophotometric assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5184028 | — | — | 1 | 8.70 |
| CHEMBL5178774 | — | — | 1 | 7.85 |
| CHEMBL5185227 | — | — | 1 | 7.52 |
| CHEMBL5208021 | — | — | 1 | 7.52 |
| CHEMBL5171024 | — | — | 1 | 7.30 |
| CHEMBL5198761 | — | — | 1 | 7.16 |
| CHEMBL5207635 | — | — | 1 | 7.16 |
| CHEMBL5187896 | — | — | 1 | 7.00 |
| CHEMBL5180136 | — | — | 1 | 6.70 |
| CHEMBL5186759 | — | — | 1 | 6.52 |
| CHEMBL5179417 | — | — | 1 | 6.40 |
| CHEMBL5197487 | — | — | 1 | 6.16 |
| CHEMBL5180101 | — | — | 1 | 6.10 |
| CHEMBL5205733 | — | — | 1 | 6.00 |
| CHEMBL5170511 | — | — | 1 | 6.00 |
| CHEMBL5176444 | — | — | 1 | 5.62 |
| CHEMBL5185264 | — | — | 1 | 5.52 |
| CHEMBL5180341 | — | — | 1 | 5.22 |
| CHEMBL5193549 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5184028 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5178774 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5185227 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5208021 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5171024 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL5198761 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL5207635 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL5187896 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5180136 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL5186759 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL5179417 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL5197487 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL5180101 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL5205733 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL5170511 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL5176444 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL5185264 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL5180341 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL5193549 | — | Ki | = | 13000.0 | nM | 4.89 |